In vivo visualisation
Single-photon emission computed tomography (SPECT) is used to visualize in vivo time profiles of cerebral blood flow following transient middle cerebral artery occlusion in rats. A lipophilic molecule, hexamethylpropylene amine oxime (HMPAO) radiolabeled with 99mTc ions is applied to image cerebral blood flow. 99mTc-HMPAO molecules are taken up by brain which are thought to be transformed to a hydrophilic complex which in exchange hence are entrapped within the cells, allowing for monitoring of brain perfusion.
Motor Pharmacology utilizes state-of-the-art microscopy arsenal including fluorescence microscope with automatized sample stage and detection system, confocal microscope, spinning disc microscope and two-photon microscope with wide range laser spectrum including UV and infra-red ranges.
The two-photon microscope is combined with ultra-rapid camera which combination allows the detections of fast behavioural movements of the animal and its neuronal processes simultaniously.