Molecular tattoo

Localization of drug effects at subcellular resolution

We developed Molecular Tattoo, a novel tool in optopharmacology. It enables the localization of drug effects with subcellular resolution in live biological objects, including whole animals. Molecular Tattoo combines photoaffinity-labeling with two-photon microscopy. Precise sequential laser irradiation is used to covalently bind photoreactive drugs present in low concentrations to their specific targets. This results in a strong and long-lasting drug effect that is restricted solely to the irradiated area.

Main features:
• precise and long-lasting effect localization
• no systemic and side effects outside the target area
• scaling of the targeted area: from organs or cell groups down to subfemtoliter volumes
• the usual in vitro and in vivo samples can be used without genetic modification.

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