Targeting Myosin by Blebbistatin Derivatives: Optimization and Pharmacological potential. 

Rauscher AÁ, Gyimesi M, Kovács M, Málnási-Csizmadia A

PubMed Abstract

Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.

Tang W, Blair CA, Walton SD, Málnási-Csizmadia A, Campbell KS, Yengo CM

PubMed Abstract

A highly soluble, non-phototoxic, non-fluorescent blebbistatin derivative.

Várkuti BH, Képiró M, Horváth Á, Végner L, Ráti S, Zsigmond Á, Hegyi G, Lenkei Z, Varga M, Málnási-Csizmadia A.

PubMed Abstract Full Text

Molecular Tattoo: Subcellular Confinement of Drug Effects.

Képiró M, Várkuti BH, Rauscher AA, Kellermayer MS, Varga M, Málnási-Csizmadia A.

PubMed Abstract Full Text

para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor.

Képiró M, Várkuti BH, Végner L, Vörös G, Hegyi G, Varga M, Málnási-Csizmadia A.

Magnesium modulates actin binding and ADP release in myosin motors.

Swenson AM, Trivedi DV, Rauscher AA, Wang Y, Takagi Y, Palmer BM, Málnási-Csizmadia A, Debold EP, Yengo CM.

PubMed Abstract


A novel actin binding site of myosin required for effective muscle contraction.

Várkuti BH, Yang Z, Kintses B, Erdélyi P, Bárdos-Nagy I, Kovács AL, Hári P, Kellermayer M, Vellai T, Málnási-Csizmadia A.

E-mail reprint request PubMed Abstract


Azidoblebbistatin, a photoreactive myosin inhibitor.

Képiró M, Várkuti BH, Bodor A, Hegyi G, Drahos L, Kovács M, Málnási-Csizmadia A.

E-mail reprint request PubMed Abstract Full Text

Myosin cleft closure determines the energetics of the actomyosin interaction.

Takács B, O’Neall-Hennessey E, Hetényi C, Kardos J, Szent-Györgyi AG, Kovács M.

PubMed Abtract

Emerging complex pathways of the actomyosin powerstroke.

Málnási-Csizmadia A, Kovács M.

PubMed Abstract Full Text


The mechanism of the reverse recovery-step, phosphate release, and actin activation of Dictyostelium myosin II.

Gyimesi M, Kintses B, Bodor A, Perczel A, Fischer S, Bagshaw CR, Málnási-Csizmadia A.

PubMed Abstract


Kinetic Characterization of the Function of Myosin Loop 4 in the Actin-Myosin Interaction.

Gyimesi M, Tsaturyan AK, Kellermayer MS, Malnasi-Csizmadia A.

E-mail reprint request PubMed Abstract

Reversible movement of switch 1 loop of myosin determines actin interaction.

Kintses B, Gyimesi M, Pearson DS, Geeves MA, Zeng W, Bagshaw CR, Málnási-Csizmadia A.

PubMed Abstract

Mechanism of blebbistatin inhibition of myosin II.

Kovács M, Tóth J, Hetényi C, Málnási-Csizmadia A, Sellers JR.

PubMed Abstract